分类筛选
分类筛选:

关于鼻咽癌论文范文资料 与102例多位鼻咽癌患者细胞免疫功能状态和预后关系有关论文参考文献

版权:原创标记原创 主题:鼻咽癌范文 科目:论文范文 2024-01-26

《102例多位鼻咽癌患者细胞免疫功能状态和预后关系》:本论文可用于鼻咽癌论文范文参考下载,鼻咽癌相关论文写作参考研究。

摘 要 目的:研究鼻咽癌患者细胞免疫功能状态和其预后的关系.方法:对符合入组条件的102例鼻咽癌患者进行T淋巴细胞亚群检测,根据CD4+/CD8+比值分为正常组(n等于61)及降低组(n等于41),两组患者均行根治性放疗及化学治疗,治疗后观察疗效并对两组患者资料进行对比,统计两组的肿瘤未控率(残留+复发)及远处转移率.结果:治疗结束3个月后鼻咽部和/或颈部残留者共9例,其中正常组5例,降低组4例;随访中鼻咽和/或颈部复发者4例,其中正常组2例,降低组2例,两组患者局部未控率(残留+复发)比较无统计学差异(P等于0.868 0);发生远处转移者16例,其中正常组5例,降低组11例,两组患者远处转移率比较,降低组明显增多,有统计学差异(P等于0.023 9).结论:鼻咽癌的细胞免疫功能状态和患者的预后有关,CD4+/CD8+值降低者远处转移率明显升高,细胞免疫功能状态低下者预后差.

关键词 鼻咽肿瘤 细胞免疫 预后

中图分类号:R739.63 文献标识码:B 文章编号:1006-1533(2017)11-0051-03

Relationship between cellular immune function and prognosis in 102 patients with nasopharyngeal carcinoma

WU Wei

(Department of Radiation and Chemotherapy, Ganzhou Cancer Hospital in Jiangxi Province, Ganzhou 341000, China)

ABSTRACT Objective: To investigate the distribution of cellular immune state in patients with nasopharyngeal carcinoma and its relationship with prognosis. Methods: Detection of T lymphocyte subsets was performed in 102 cases of nasopharyngeal carcinoma patients met the entry criteria and they were divided into a normal group (n等于61) and a lower group (n等于41) based on the ratio of CD4+ and CD8+. All the patients underwent radical radiotherapy and chemotherapy, and the therapeutic effects were observed and compared after treatment. Tumor control failure rate (residual + recurrence) and distant metastasis rate were statistically analyzed. Results: There were 9 cases in the nasopharynx and/or residual neck after 3 months of treatment, in which there were 5 cases in the normal group and 4 cases in the lower group. Four cases of nasopharyngeal and/ or neck recurrence were found during follow-up, in which there were 2 cases in the normal group and in the lower group and the comparison of local control failure rate (residual + recurrence) showed no statistical significance (P等于0.868 0); There were 5 cases of distant metastasis in the normal group and 11 cases in the lower group and the distant metastasis rate was significantly higher in the lower group than in the normal group (P等于0.023 9). Conclusion: The cellular immune function of nasopharyngeal carcinoma is related to the prognosis of patients. The distant metastasis rate is obviously higher in patients with lower CD4+/CD8+ value, and the prognosis is poor in patients with low cellular immune function.

KEY WORDS nasopharyngeal carcinoma; cellular immune; prognosis

鼻咽癌是我國南方常见的恶性肿瘤,主要的治疗方法是放射治疗,随着对该病生物学行为进一步的了解及治疗技术的不断提高,总体治疗效果理想,但仍有一部分患者出现残留、复发及转移.现代肿瘤免疫学研究表明,肿瘤的发生、发展、复发、转移等生物学行为,均和其免疫功能状态有关,除了肿瘤的临床分期、综合治疗模式以外,患者的免疫功能状态有可能是影响其预后的一个重要因素.本研究对我院2014年12月—2016年6月102例初诊鼻咽癌患者进行T淋巴细胞亚群检测,观察及统计检测结果和患者治疗预后的关系.

鼻咽癌论文参考资料:

结论:102例多位鼻咽癌患者细胞免疫功能状态和预后关系为关于鼻咽癌方面的的相关大学硕士和相关本科毕业论文以及相关鼻癌的最明显症状论文开题报告范文和职称论文写作参考文献资料下载。

和你相关的