原创《丁苯酞对脑小血管病患者认知功能、脑血流灌注影响》：该文是关于脑血论文范文，为你的论文写作提供相关论文资料参考。
[摘 要] 目的 观察分析丁苯酞对脑小血管病患者认知功能及脑血流灌注的影响. 方法 方便选取2014年5月—2016年5月在该院和入组条件相符的60例脑小血管病患者依据随机分组法均分为3组,每组均为20例,疗程均为1个月.治疗前后均对全部患者实施蒙特利尔量表（MOCA）评分.B、C两组均随意择取10例在治疗前后实施64排螺旋CT灌注成像检验,并对灌注指数值进行测算,并对临床效果实施评价. 结果 58例患者最后均结束实验.MOCA 总分值改变：B组和C组经治疗MOCA分值（22.02±2.060）分及（21.53±1.960）分和治疗前（19.14±1.720）分及（19.10±1.796）分比較显著改进（P<0.05）；C组通过治疗于语言、注意力和计算力、视空间和执行力、延迟记忆力和抽象评分的改变具有可比性（P<0.05）.结论 应用丁苯酞能够改进脑小血管病患者的意识,而且还能有效增强局部脑灌注量,其治疗效果并不比尼莫地平片低,而且没有发现不良情况.
[关键词] 丁苯酞软胶囊；脑小血管病；认知功能；CT 灌注成像
[中图分类号] R71 [文献标识码] A [文章编号] 1674-0742（2017）12（b）-0130-03
[Abstract] Objective To observe and analyze the effect of butyphthalide on the cognitive function and brain perfusion of patients with cerebral small vascular disease. Methods 60 cases of patients with cerebral small vascular diseases in our hospital from May 2014 to May 2016 were convenient selected and randomly divided into three groups with 20 cases in each, the treatment course was 1 month, and all patients were scored by the MOCA, and 10 cases and 10 cases in the group B and in the group C were randomly selected for 64 spiral CT perfusion imaging test, and the perfusion index value was calculated, and the clinical effect was evaluated. Results 58 cases had finished experiments finally, total MOCA value changes： the MOCA scores in the group B and in the group C after treatment were obviously improved compared with those before treatment,[（22.02±2.060）points,（21.53±1.960）points, vs （19.14±1.720）points,（19.10±1.796）points]（P<0.05）, and the differences in the language, attention, calculation, visual space, execution, delaying the memory and changes of abstract scores were statistically significant（P<0.05）. Conclusion The application of butyphthalide can improve the awareness of patients with?cerebral small vascular disease, effectively enhance the local brain perfusion amount, and the treatment effect is not lower than that of nimodipine tablets, and there are no adverse reactions.
[Key words] Butylphthalide soft capsules； Cerebral small vascular disease； Cognitive function； CT perfusion imaging
现阶段,由于影像技能的迅猛进步,患脑小血管病的老年人数量正在逐步增加.其患病原因均是由相应的动脉粥样硬化所致,但小血管病的发病因素迄今为止仍然不清楚[1].但小血管病对两种组织的伤害程度完全不同,相关损伤潜藏着相关隐匿性和持续性两种特征[2].临床中最显著的特征就是意识逐渐降低,执行力缓慢,并发展为血管性痴呆,从而给患者的日常生活带来很大的影响,也因此加重家庭及社会的负担[3].该研究于2014年5月—2016年5月检验丁苯酞软胶囊在有关脑小血管病患者意识评估的影响的改进量表属于（北京协和医院和Z.Nasreddine 协商中文版）（Montreal cognitive assessment,Mo CA）,并观察丁苯酞治疗前后相应的兴趣区脑器官的血流动力改变,并观察分析其对脑小血管病的临床效果及可能机制[4],现报道如下.
1 资料和方法
1.1 一般资料
方便选取在该院神经内科和门诊有意识主诉且CT或MRI证明符合入组指标的患者60例收集为研究对象.
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结论：丁苯酞对脑小血管病患者认知功能、脑血流灌注影响为大学硕士与本科脑血毕业论文开题报告范文和相关优秀学术职称论文参考文献资料下载，关于免费教你怎么写老血栓是什么症状方面论文范文。
