原创《舍曲林联合利培酮治疗精神分裂症阴性症状临床观察》：本论文可用于舍曲林论文范文参考下载，舍曲林相关论文写作参考研究。
【摘 要】 目的 观察舍曲林联合利培酮治疗精神分裂症阴性症状的临床效果.方法 80例精神分裂症患者, 随机分为对照组和观察组, 各40例.对照组给予利培酮治疗, 观察组给予舍曲林联合利培酮治疗, 对比两组治疗前后阴性症状评分.结果 治疗前, 两组情绪退缩、情感迟钝、被动社交退缩、情感交流障碍、刻板思维、抽象思维障碍评分比较差异无统计学意义（P>0.05）.治疗后, 观察组情绪退缩（3.5±0.7）分、情感迟钝（3.5±1.1）分、被动社交退缩（3.8±0.8）分、情感交流障碍（3.4±1.0）分均低于对照组的（4.8±1.2）、（4.7±1.2）、（4.5±1.4）、（4.5±1.2）分, 差异有统计学意义（P<0.05）;两组刻板思维、抽象思维障碍评分比较差异无统计学意义（P>0.05）.结论 舍曲林联合利培酮治疗精神分裂症, 可显著改善其阴性症状, 值得采纳应用.
【关键词】 舍曲林;利培酮;精神分裂症阴性症状;临床效果
DOI：10.14163/j.cnki.11-5547/r.2018.03.049
【Abstract】 Objective To observe the clinical effect of sertraline combined with risperidone in the treatment of negative symptoms of schizophrenia. Methods A total of 80 schizophrenia patients were randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with risperidone, and the observation group was treated with sertraline combined with risperidone. Negative symptom score before and after treatment was compared in two groups. Results Before treatment, both groups had no statistically significant difference in emotional recession, emotional slowness, passive social withdrawal, emotional communication disorder, stereotyped thinking and abstract thinking disorder score （P>0.05）. After treatment, the observation group had emotional recession score as （3.5±0.7） points, emotional slowness score as （3.5±1.1） points, passive social withdrawal score as （3.8±0.8） points and emotional communication disorder score as （3.4±1.0） points, which were all lower than （4.8±1.2）, （4.7±1.2）, （4.5±1.4） and （4.5±1.2） points in the control group, and their difference was statistically significant （P<0.05）. Both groups had no statistically significant difference in stereotyped thinking and abstract thinking disorder score （P>0.05）. Conclusion Combination of sertraline and risperidone in treating schizophrenia can significantly improve the negative symptoms, and is worthy of adoption and application.
【Key words】 Sertraline; Risperidone; Negative symptoms of schizophrenia; Clinical effect
精神分裂癥（schizophrenia）是一组大脑功能和精神活动异常的精神疾病, 其性质较为严重, 患者意识清晰, 智能如常, 但是存在着感知觉、行为、思维、情感等多方面的异常症状[1].根据其主导临床症状, 按照中国精神障碍分类和诊断标准第3版（CCMD-3）, 可将其分为偏执型分裂症、青春型分裂症、紧张型分裂症、单纯型分裂症以及未定型分裂症5种症型[2].该疾病起病缓慢, 但是难以治愈, 易长期反复发作, 需根据其病因病机给予对症治疗.本次试验旨在探究舍曲林联合利培酮治疗精神分裂症阴性症状的临床效果, 结果报告如下.
1 资料和方法
1. 1 一般资料 选取2016年1月～2017年6月在本院治疗的精神分裂症患者80例作为研究对象, 随机分为对照组和观察组, 各40例.对照组男女比例24∶16, 年龄32～58岁, 平均年龄（43.12±5.25）岁;病程4～17年, 平均病程（10.13±2.69）年.
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结论：舍曲林联合利培酮治疗精神分裂症阴性症状临床观察为适合舍曲林论文写作的大学硕士及相关本科毕业论文，相关盐酸舍曲林能治早射吗开题报告范文和学术职称论文参考文献下载。
