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《桂西地区脊柱结核患者血清IL27的检测与其临床意义》：这篇桂西论文范文为免费优秀学术论文范文,可用于相关写作参考。

【摘 要】目的检测脊柱结核患者血清白细胞介素27（IL27）的表达水平,以探讨其临床意义.方法选择2016年1～5月收治的30例脊柱结核患者作为观察组,同期选择在体检中心进行健康体检的32名健康者作为对照组,应用酶联免疫吸附法检测两组血清IL27的表达含量,同时采用常规方法检测C反应蛋白（CRP）和红细胞沉降率（ESR）,比较两组间IL27、CRP及ESR表达含量的差异,分析观察组IL27水平与CRP、ESR水平之间的线性关系.结果两组受试者血清IL27、CRP及ESR表达含量差异有统计学意义（P<0.01）,观察组IL27、CRP及ESR水平均显著高于对照组；观察组患者血清IL27与CRP、ESR水平均无线性相关（P>0.05）.结论脊柱结核患者血清IL27的表达水平升高,提示其可能参与脊柱结核的发生与发展.

【关键词】脊柱结核；白细胞介素27；C反应蛋白；红细胞沉降率

中图分类号：R529.2文献标识码：ADOI：10.3969/j.issn.10031383.2016.05.002

【Abstract】ObjectiveTo detect the expression level of serum Interleukin27 （IL27） in patients with spinal tuberculosis,so as to explore its clinical significance.Methods30 cases of spinal tuberculosis admitted to hospital from January to May,2016 were selected as observation group,and 32 healthy subjects who received physical examination in physical examination center during the same period were chosen as control group.The serum levels of IL27 in the control group and the observation group were measured by enzyme linked immunosorbent assay.And the C reactive protein （CRP） and erythrocyte sedimentation rate（ESR） were detected by routine method.The differences of IL27,CRP and ESR levels between the two groups were compared,and the linear correlation between IL27 and CRP,ESR levels in the observation group was analyzed.ResultsDifference of the IL27,CRP and ESR expression contents of the two groups was statistically significant（P<0.01）,and those in the observation group were significantly higher than those in the control group.There was no significant linear correlation of the serum IL27 with CRP and ESR levels in the observation group （P>0.05）.ConclusionThe level of serum IL27 in patients with spinal tuberculosis increase,suggesting that it may involve in the occurrence and development of spinal tuberculosis.

【Key words】spinal tuberculosis；IL27；CRP；ESR

脊柱結核（spinal tuberculosis）是由结核分枝杆菌引起的,属于肺外结核的一种脊柱感染性疾病.其患病率约占骨关节结核的50%[1].近年来,随着流动人口,AIDS患者及耐药结核分枝杆菌的增加,脊柱结核的发病率日益增多.由于脊柱结核极易并发瘘管、窦道及关节畸形等,甚至出现截瘫[2],严重影响患者的生活质量及预期寿命,其已经成为我国公共卫生亟待解决的重要问题.目前,脊柱结核的确切发病机制尚未明确.白细胞介素27（interleukin27,IL27）是一种多效性细胞因子,具有促进和抑制炎症的双重作用,主要由巨噬细胞、树突状细胞及单核细胞等抗原提呈细胞产生.其基因位于人第16号染色体上（16p11）,由两个亚基组成：EB病毒诱导基因3（EBI3）和p28[3].相关资料显示[4,5],IL27参与肺结核的发生与发展,在肺结核的免疫调节中发挥重要的作用.本研究应用酶联免疫吸附法（enzymelinked immunosorbent assay,ELISA）对30例桂西地区脊柱结核患者及32名健康者的血清IL27水平进行检测,同时结合C反应蛋白（CRP）和红细胞沉降率（ESR）进行相关性分析,以初步探索IL27在脊柱结核发病机制中的作用.

1资料与方法1.1收集资料选择2016年1～5月右江民族医学院附属医院收治住院的30例脊柱结核患者作为观察组,男性19例,女性11例,年龄36～67岁,平均（49.58±8.82）岁.同期随机选择在本院体检中心进行健康体检的32名健康者作为对照组,男性15名,女性17名,年龄28～70岁,平均（45.21±9.15）岁,入选者近期无结核病接触史或感染性疾病,影像学及临床指标检查均未提示异常.本研究获得右江民族医学院附属医院*委员会批准,所有受试者知情并签署知情同意书.

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