原创《痛风患者并发急性肾损伤的相关因素分析》：此文是一篇肾损伤论文范文,为你的毕业论文写作提供有价值的参考。
【摘 要】 目的 分析痛风患者并发急性肾损伤的相关因素.方法 87例痛风患者, 根据是否并发急性肾损伤分为急性肾损伤组（20例）和非急性肾损伤组（67例）.对比两组患者临床资料, 并通过单因素分析及多因素分析总结痛风患者并发急性肾损伤的相关因素.结果 单因素分析显示, 急性肾损伤组患者并发中晚期慢性肾脏病（CKD）比例及入院前使用非甾体类消炎药（NSAIDs）比例高于非急性肾损伤组, 入院血肌酐水平、入院血尿酸水平高于非急性肾损伤组, 血红蛋白水平低于非急性肾损伤组, 差异均具有统计学意义（P<0.05）.两组患者的24 h尿蛋白阳性率、尿α1微球蛋白阳性率、血浆白蛋白、尿pH值、24 h尿酸排泄量比较, 差异均无统计学意义（P>0.05）.经Logistic分析发现, NSAIDs使用比例、中晚期CKD比例、血尿酸水平及血肌酐水平是急性肾损伤发生的独立危险因素 （P<0.05）.结论 NSAIDs使用比例、中晚期CKD、血尿酸及血肌酐水平升高是痛风患者并发急性肾损伤的独立危险因素, 采取有效措施进行预防可降低急性肾损伤发生率.
【关键词】 痛风；急性肾损伤；相关因素
DOI：10.14163/j.cnki.11-5547/r.2017.19.020
Analysis of related factors of acute renal injury in gout patients LI Gui-xia. Shenzhen City Third People’s Hospital, Shenzhen 517112, China
【Abstract】 Objective To analyze the related factors of acute renal injury in gout patients. Methods A total of 87 gout patients were divided by whether complicated with acute renal injury or not into acute renal injury group （20 cases） and non-acute renal injury group （67 cases）. The clinical data of the two groups were compared, and the related factors of acute renal injury in gout patients were analyzed by single factor analysis and multi factor analysis. Results Single factor analysis showed that acute renal injury group had higher proportion of patients complicated with chronic renal disease （CKD） and the proportion of non steroidal anti-inflammatory drugs （NSAIDs）using before hospitalization than non-acute renal injury group, higher admission serum creatinine level and blood uric acid level than non-acute renal injury group, and lower hemoglobin level than non-acute renal injury group. Their difference had statistical significance （P<0.05）. Both groups had no statistically significant difference in 24 h urine protein positive rate, urine α 1 microsphere positive rate, plasma albumin, urine pH value and 24 h
uric acid excretion amount （P>0.05）. Logistic analysis showed that NSAIDs use ratio, middle-late CKD ratio, serum uric acid level and serum creatinine level are independent risk factors for acute kidney injury （P<0.05）. Conclusion NSAIDs use ratio, middle-late CKD, elevated levels of serum uric acid and serum creatinine are independent risk factors for acute kidney injury in gout patients, and effective measures can reduce the incidence of acute kidney injury.
【Key words】 Gout； Acute renal injury； Related factors
嘌呤代謝紊乱和血尿酸升高是痛风发生的主要原因, 易损伤内脏, 特别是肾脏, 严重将引发肾衰竭, 对患者生命造成影响[1].急性肾损伤具有起病急、病情发展快的特点, 如果不能及时进行诊断, 易引发肾脏不可逆损伤, 发展成慢性肾脏病, 增加治疗的困难程度.有关研究表明[2], 痛风患者发生急性肾损伤的几率明显高于普通人群.因此, 对痛风患者并发急性肾损伤的因素进行分析, 有助于降低急性肾损伤发生率.本研究对本院87例痛风患者进行研究, 旨在探讨痛风患者并发急性肾损伤的相关因素.现报告如下.
肾损伤论文参考资料：
结论：痛风患者并发急性肾损伤的相关因素分析为关于本文可作为相关专业肾损伤论文写作研究的大学硕士与本科毕业论文肾损伤论文开题报告范文和职称论文参考文献资料。
